I am utilizing the 3D printed enclosures, and while I know there is no air exchange between the enclosures and the outside I feel like I could still benefit from active cooling.
Would absolutely go with the active cooler for the Pi 5. I was running these at below freezing here in Denmark and without any cooling they were still overheating inside the plastic enclosure.
With the active cooler they were operating great and the plastic does warm up considerably. I would recommend making sure the fan kicks in earlier - the wireless display lets you toggle the fan on/off auto.
I did some testing with this and it running a YOLO model on CPU with/without fan and overclocked.
This is with the fan running full, stabilised about 67C - otherwise it overheated at 85C and shutdown.
The only potential issue that @pvouzis identified with the fan is that you now have a moving part in a high vibration area - so there is some failure risk here. We haven’t any issues yet, but it seems a matter of time x scale for it to happen. Hence the interest in the new design for passive cooling through the alu case.